DHRS3

DHRS3
Identifiers
Aliases	DHRS3, DD83.1, RDH17, Rsdr1, SDR1, SDR16C1, retSDR1, dehydrogenase/reductase (SDR family) member 3, dehydrogenase/reductase 3
External IDs	OMIM: 612830; MGI: 1315215; HomoloGene: 20994; GeneCards: DHRS3; OMA:DHRS3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	12,618,210 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	144,654,779 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; right lobe of liver; ; tibial nerve; ; right lobe of thyroid gland; ; nasal epithelium; ; left lobe of thyroid gland; ; prostate; ; olfactory zone of nasal mucosa; ; seminal vesicula; ; subcutaneous adipose tissue;
	Top expressed in
	vestibular membrane of cochlear duct; ; transitional epithelium of urinary bladder; ; left lobe of liver; ; right kidney; ; neural layer of retina; ; external carotid artery; ; proximal tubule; ; lobe of prostate; ; epithelium of stomach; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	electron transfer activity; nucleotide binding; oxidoreductase activity; NAD-retinol dehydrogenase activity; NADP-retinol dehydrogenase activity;
Cellular component	photoreceptor outer segment membrane; integral component of membrane; endoplasmic reticulum membrane; membrane; lipid droplet;
Biological process	negative regulation of retinoic acid receptor signaling pathway; retinol metabolic process; roof of mouth development; bone morphogenesis; outflow tract morphogenesis; regulation of ossification; visual perception; retinoid metabolic process; cardiac septum morphogenesis; electron transport chain; regulation of retinoic acid receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9249
	20148
	ENSG00000162496
	ENSMUSG00000066026
	O75911; Q5SUY4
	O88876
	NM_004753; NM_001319225; NM_001324370
NM_001172424; NM_011303; NM_001357274; NM_001357275; NM_001357276;
	NM_001357277
	NP_001306154; NP_001311299; NP_004744
NP_001165895; NP_035433; NP_001344203; NP_001344204; NP_001344205;
	NP_001344206
	Wikidata
View/Edit Human	View/Edit Mouse

Short-chain dehydrogenase/reductase 3 is an enzyme that in humans is encoded by the DHRS3 gene.^[5]^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162496 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066026 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K (Sep 1998). "Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal". J Biol Chem. 273 (34): 21790–9. doi:10.1074/jbc.273.34.21790. PMID 9705317.
^ Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina". J Biol Chem. 277 (47): 45537–46. doi:10.1074/jbc.M208882200. PMC 1435693. PMID 12226107.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: DHRS3 dehydrogenase/reductase (SDR family) member 3".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Cerignoli F, Guo X, Cardinali B, et al. (2002). "retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines". Cancer Res. 62 (4): 1196–204. PMID 11861404.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Roni V, Carpio R, Wissinger B (2007). "Mapping of transcription start sites of human retina expressed genes". BMC Genomics. 8: 42. doi:10.1186/1471-2164-8-42. PMC 1802077. PMID 17286855.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162496 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066026 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9705317-5] Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K (Sep 1998). "Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal". J Biol Chem. 273 (34): 21790–9. doi:10.1074/jbc.273.34.21790. PMID 9705317.

[pmid12226107-6] Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina". J Biol Chem. 277 (47): 45537–46. doi:10.1074/jbc.M208882200. PMC 1435693. PMID 12226107.

[pmid19027726-7] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-8] "Entrez Gene: DHRS3 dehydrogenase/reductase (SDR family) member 3".

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References

Further reading