FABP7

FABP7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FDQ, 1FE3, 1JJX
Identifiers
Aliases	FABP7, B-FABP, BLBP, FABPB, MRG, LTR2-fatty acid binding protein 7
External IDs	OMIM: 602965; MGI: 101916; HomoloGene: 37880; GeneCards: FABP7; OMA:FABP7 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	122,784,074 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	57,664,546 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; cerebellar vermis; ; spinal ganglia; ; skin of thigh; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; paraflocculus of cerebellum; ; amygdala; ; vulva;
	Top expressed in
	olfactory bulb; ; medial ganglionic eminence; ; ventricular zone; ; trigeminal ganglion; ; barrel cortex; ; optic nerve; ; superior cervical ganglion; ; neural tube; ; olfactory epithelium; ; fossa;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	lipid binding;
Cellular component	cell body; soma; cell projection; cell periphery; nucleus; cell-cell junction; cytoplasm; cytosol;
Biological process	negative regulation of cell population proliferation; triglyceride catabolic process; neurogenesis; epithelial cell proliferation; cell proliferation in forebrain; startle response; nervous system development; prepulse inhibition;
	Sources:Amigo / QuickGO
Orthologs
	2173
	12140
	ENSG00000164434
	ENSMUSG00000019874
	O15540
	P51880
	NM_001446; NM_001319039; NM_001319041; NM_001319042
	NM_021272
	NP_001305968; NP_001305970; NP_001305971; NP_001437
	NP_067247
	Wikidata
View/Edit Human	View/Edit Mouse

Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.^[5]

Function

The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.^[5]

FABP7 is expressed, during development, in radial glia by the activation of Notch receptors.^[6] Reelin was shown to induce FABP7 expression in neural progenitor cells via Notch-1 activation.^[7]

According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs.^[8]

Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and radial glia, where neurogenesis is prominent.

Role in pathology

FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis.^[9]

As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia,^[10] with one, that tested for only one SNP, showing negative^[11] and another, with seven SNPs,^[12] a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164434 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019874 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: FABP7 fatty acid binding protein 7, brain".
^ Anthony TE, Mason HA, Gridley T, Fishell G, Heintz N (May 2005). "Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells". Genes & Development. 19 (9): 1028–33. doi:10.1101/gad.1302105. PMC 1091737. PMID 15879553.
^ Keilani S, Sugaya K (July 2008). "Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1". BMC Developmental Biology. 8 (1): 69. doi:10.1186/1471-213X-8-69. PMC 2447831. PMID 18593473.
^ Xu LZ, Sánchez R, Sali A, Heintz N (Oct 1996). "Ligand specificity of brain lipid-binding protein". The Journal of Biological Chemistry. 271 (40): 24711–9. doi:10.1074/jbc.271.40.24711. PMID 8798739.
^ Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, Schwab SG, Pulver AE, Faraone SV, Brzustowicz LM, Kaufmann CA, Garver DL, Gurling HM, Lindholm E, Coon H, Moises HW, Byerley W, Shaw SH, Mesen A, Sherrington R, O'Neill FA, Walsh D, Kendler KS, Ekelund J, Paunio T, Lönnqvist J, Peltonen L, O'Donovan MC, Owen MJ, Wildenauer DB, Maier W, Nestadt G, Blouin JL, Antonarakis SE, Mowry BJ, Silverman JM, Crowe RR, Cloninger CR, Tsuang MT, Malaspina D, Harkavy-Friedman JM, Svrakic DM, Bassett AS, Holcomb J, Kalsi G, McQuillin A, Brynjolfson J, Sigmundsson T, Petursson H, Jazin E, Zoëga T, Helgason T (Jul 2003). "Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia". American Journal of Human Genetics. 73 (1): 34–48. doi:10.1086/376549. PMC 1180588. PMID 12802786.
^ Gene Overview of All Published Schizophrenia-Association Studies for FABP7 - SZGene database at Schizophrenia Research Forum website.
^ Jungerius BJ, Hoogendoorn ML, Bakker SC, Van't Slot R, Bardoel AF, Ophoff RA, Wijmenga C, Kahn RS, Sinke RJ (Nov 2008). "An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia". Molecular Psychiatry. 13 (11): 1060–8. doi:10.1038/sj.mp.4002080. PMID 17893707.
^ Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, Matsumata M, Ishitsuka Y, Nakaya A, Maekawa M, Ohnishi T, Arai R, Sakurai K, Yamada K, Kondo H, Hashimoto K, Osumi N, Yoshikawa T (Nov 2007). "Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype". PLOS Biology. 5 (11): e297. doi:10.1371/journal.pbio.0050297. PMC 2071943. PMID 18001149.

External links

Schizophrenia, Startled Response & Fabp7: Future Dietary Changes for At-Risk Mothers? Schizophrenia Daily News Blog, 2007-11-07
Gross L (2007). "A Candidate Gene for a Biological Marker of Schizophrenia in Mice". PLOS Biology. 5 (11): e320. doi:10.1371/journal.pbio.0050320. PMC 2071941. PMID 20076655. - a synopsis for the general audience.
Overview of all the structural information available in the PDB for UniProt: O15540 (Fatty acid-binding protein, brain) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164434 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019874 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FABP7 fatty acid binding protein 7, brain".

[pmid15879553-6] Anthony TE, Mason HA, Gridley T, Fishell G, Heintz N (May 2005). "Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells". Genes & Development. 19 (9): 1028–33. doi:10.1101/gad.1302105. PMC 1091737. PMID 15879553.

[pmid18593473-7] Keilani S, Sugaya K (July 2008). "Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1". BMC Developmental Biology. 8 (1): 69. doi:10.1186/1471-213X-8-69. PMC 2447831. PMID 18593473.

[pmid8798739-8] Xu LZ, Sánchez R, Sali A, Heintz N (Oct 1996). "Ligand specificity of brain lipid-binding protein". The Journal of Biological Chemistry. 271 (40): 24711–9. doi:10.1074/jbc.271.40.24711. PMID 8798739.

[pmid12802786-9] Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, Schwab SG, Pulver AE, Faraone SV, Brzustowicz LM, Kaufmann CA, Garver DL, Gurling HM, Lindholm E, Coon H, Moises HW, Byerley W, Shaw SH, Mesen A, Sherrington R, O'Neill FA, Walsh D, Kendler KS, Ekelund J, Paunio T, Lönnqvist J, Peltonen L, O'Donovan MC, Owen MJ, Wildenauer DB, Maier W, Nestadt G, Blouin JL, Antonarakis SE, Mowry BJ, Silverman JM, Crowe RR, Cloninger CR, Tsuang MT, Malaspina D, Harkavy-Friedman JM, Svrakic DM, Bassett AS, Holcomb J, Kalsi G, McQuillin A, Brynjolfson J, Sigmundsson T, Petursson H, Jazin E, Zoëga T, Helgason T (Jul 2003). "Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia". American Journal of Human Genetics. 73 (1): 34–48. doi:10.1086/376549. PMC 1180588. PMID 12802786.

[SZGeneDB-10] Gene Overview of All Published Schizophrenia-Association Studies for FABP7 - SZGene database at Schizophrenia Research Forum website.

[pmid17893707-11] Jungerius BJ, Hoogendoorn ML, Bakker SC, Van't Slot R, Bardoel AF, Ophoff RA, Wijmenga C, Kahn RS, Sinke RJ (Nov 2008). "An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia". Molecular Psychiatry. 13 (11): 1060–8. doi:10.1038/sj.mp.4002080. PMID 17893707.

[pmid18001149-12] Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, Matsumata M, Ishitsuka Y, Nakaya A, Maekawa M, Ohnishi T, Arai R, Sakurai K, Yamada K, Kondo H, Hashimoto K, Osumi N, Yoshikawa T (Nov 2007). "Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype". PLOS Biology. 5 (11): e297. doi:10.1371/journal.pbio.0050297. PMC 2071943. PMID 18001149.

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Proteins: carrier proteins
Fatty acid	FABP1 FABP2 FABP3 FABP4 FABP5 FABP6
Hormone	peptide hormone: Follistatin Growth hormone binding protein Insulin-like growth factor binding protein IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Neurophysins Neurophysin I II steroid hormone: Sex hormone binding globulin/Androgen binding protein Transcortin Thyroxine-binding globulin Transthyretin
Metal/element	calcium Calcium-binding protein Calmodulin-binding proteins copper Ceruloplasmin iron Iron-binding proteins Transferrin receptor
Vitamin	Retinol binding protein 1 2 3 4 Transcobalamin
Pigment	Plant Light-Harvesting Complex Orange Carotenoid Protein Phycobiliprotein Photosynthetic Reaction Centers Phytochrome Rhodopsin
Other	Acyl carrier protein Adaptor protein Cholesterylester transfer protein F-box protein GTP-binding protein Latent TGF-beta binding protein Major urinary proteins Membrane transport protein Odorant binding protein

Function

Role in pathology

References

Further reading

External links