Necrobiosis

Necrobiosis
SpecialtyPathology

Necrobiosis is the physiological death of a cell, and can be caused by conditions such as basophilia, erythema, or a tumor. It is identified both with[1] and without necrosis.

Necrobiotic disorders are characterized by presence of necrobiotic granuloma on histopathology. Necrobiotic granuloma is described as aggregation of histiocytes around a central area of altered collagen and elastic fibers. Such a granuloma is typically arranged in a palisaded pattern.[2]

It is associated with necrobiosis lipoidica and granuloma annulare.

Necrobiosis differs from apoptosis, which kills a damaged cell to protect the body from harm.

References

  1. ^ eMedicine/Stedman Medical Dictionary Lookup
  2. ^ Pokharel, Achyut; Koirala, Isha Poudel (22 May 2018). "Necrobiotic granuloma: An update". Indian Journal of Dermatopathology and Diagnostic Dermatology. 5 (1): 27–33. doi:10.4103/ijdpdd.ijdpdd_12_18. S2CID 81162412.


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