Pyrimidine analogue

Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.

Examples

  • Nucleobase analogues
  • Nucleoside analogues
    • Cytarabine (Cytosine arabinoside)
    • Gemcitabine
  • Nucleotide analogues

Medical uses

Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication.[1]

References

  1. ^ Parker, William B. (2009). "Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer". Chem Rev. 109 (7): 2880–2893. doi:10.1021/cr900028p. PMC 2827868. PMID 19476376.


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