Fludroxycortide

Fludroxycortide
Clinical data
Trade names	Cordran, Haelan
Other names	6α-Fluoro-16α-hydroxyhydrocortisone 16,17-acetonide; 6α-Fluoro-11β,16α,17α,21-tetrahydroxypregn-4-ene-3,20-dione 16,17-acetonide
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Topical
ATC code	D07AC07 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only);
Identifiers
	IUPAC name 6-Fluoro-11,21-dihydroxy-16,17-[(l-methylethylidene)bis(oxy)]-(6α,11β,16α)-pregn-4-ene-3,20-dione;
CAS Number	1524-88-5 ;
PubChem CID	15209;
IUPHAR/BPS	7606;
DrugBank	DB00846 ;
ChemSpider	14475 ;
UNII	8EUL29XUQT;
KEGG	D00328 ;
ChEMBL	ChEMBL1201012 ;
CompTox Dashboard (EPA)	DTXSID2047434 ;
ECHA InfoCard	100.014.724
Chemical and physical data
Formula	C24H33FO6
Molar mass	436.520 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1\C=C5/[C@](C)(CC1)[C@@H]2[C@H]([C@H]3[C@](C[C@@H]2O)([C@@]4(OC(O[C@@H]4C3)(C)C)C(=O)CO)C)C[C@@H]5F;
	InChI InChI=1S/C24H33FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h7,13-14,16-17,19-20,26,28H,5-6,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1 ; Key:POPFMWWJOGLOIF-XWCQMRHXSA-N ;
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Fludroxycortide (INN, BAN, JAN), also known as flurandrenolide (USAN) and flurandrenolone,^[1] is a synthetic topical corticosteroid and is used as an anti-inflammatory treatment for use on skin irritations. Trade names include Haelan (Typharm, UK) and Cordran (by Watson Pharmaceuticals, US).^[2]^[3]

Fludroxycortide is available in ointment, cream and as an impregnated tape (Haelan tape, Cordran tape). Licensed indications in the United Kingdom include recalcitrant dermatoses.^[4]^[5]

References

^ CID 15209 from PubChem
^ "Fludroxycortide". Drugs.com. Archived from the original on 2019-08-29. Retrieved 2018-01-23.
^ "Fludroxycortide". Patient.info. 30 August 2022.
^ Haelan Tape Summary of Product Characteristics
^ Nakamura H, Motoyoshi S, Ishii K, Seto Y, Shimizu M (October 1980). "[Anti-inflammatory activity of a topical glucocorticoid, fludroxycortide tape in experimental animals (author's transl)]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 76 (7): 595–607. doi:10.1254/fpj.76.595. PMID 7215997.

[1] CID 15209 from PubChem

[2] "Fludroxycortide". Drugs.com. Archived from the original on 2019-08-29. Retrieved 2018-01-23.

[3] "Fludroxycortide". Patient.info. 30 August 2022.

[4] Haelan Tape Summary of Product Characteristics

[5] Nakamura H, Motoyoshi S, Ishii K, Seto Y, Shimizu M (October 1980). "[Anti-inflammatory activity of a topical glucocorticoid, fludroxycortide tape in experimental animals (author's transl)]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 76 (7): 595–607. doi:10.1254/fpj.76.595. PMID 7215997.

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