List of EC numbers (EC 4)

This list contains a list of EC numbers for the fourth group, EC 4, lyases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee.[1] The database is developed and maintained by Andrew McDonald.[2]

EC 4.1: Carbon-Carbon Lyases

EC 4.1.1: Carboxy-lyases

EC 4.1.2: Aldehyde-lyases

  • EC 4.1.2.1: Now included with EC 4.1.3.16 4-hydroxy-2-oxoglutarate aldolase
  • EC 4.1.2.2: ketotetrose-phosphate aldolase
  • EC 4.1.2.3: deleted, was pentosealdolase.
  • EC 4.1.2.4: deoxyribose-phosphate aldolase
  • EC 4.1.2.5: L-threonine aldolase
  • EC 4.1.2.6: Deleted, reaction is due to EC 2.1.2.1, glycine hydroxymethyltransferase
  • EC 4.1.2.7: Now included with EC 4.1.2.13 fructose-bisphosphate aldolase
  • EC 4.1.2.8: indole-3-glycerol-phosphate lyase
  • EC 4.1.2.9: phosphoketolase
  • EC 4.1.2.10: (R)-mandelonitrile lyase
  • EC 4.1.2.11: hydroxymandelonitrile lyase
  • EC 4.1.2.12: 2-dehydropantoate aldolase
  • EC 4.1.2.13: fructose-bisphosphate aldolase
  • EC 4.1.2.14: 2-dehydro-3-deoxy-phosphogluconate aldolase
  • EC 4.1.2.15: Now EC 2.5.1.54, 3-deoxy-7-phosphoheptulonate synthase
  • EC 4.1.2.16: Now EC 2.5.1.55, 3-deoxy-8-phosphooctulonate synthase
  • EC 4.1.2.17: L-fuculose-phosphate aldolase
  • EC 4.1.2.18: 2-dehydro-3-deoxy-L-pentonate aldolase
  • EC 4.1.2.19: rhamnulose-1-phosphate aldolase
  • EC 4.1.2.20: 2-dehydro-3-deoxyglucarate aldolase
  • EC 4.1.2.21: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
  • EC 4.1.2.22: fructose-6-phosphate phosphoketolase
  • EC 4.1.2.23: 3-deoxy-D-manno-octulosonate aldolase
  • EC 4.1.2.24: dimethylaniline-N-oxide aldolase
  • EC 4.1.2.25: dihydroneopterin aldolase
  • EC 4.1.2.26: phenylserine aldolase
  • EC 4.1.2.27: sphinganine-1-phosphate aldolase
  • EC 4.1.2.28: 2-dehydro-3-deoxy-D-pentonate aldolase
  • EC 4.1.2.29: 5-dehydro-2-deoxyphosphogluconate aldolase
  • EC 4.1.2.30: Now EC 1.14.14.32}, 17α-hydroxyprogesterone deacetylase
  • EC 4.1.2.31: Now included with EC 4.1.3.16 4-hydroxy-2-oxoglutarate aldolase
  • EC 4.1.2.32: trimethylamine-oxide aldolase
  • EC 4.1.2.33: fucosterol-epoxide lyase
  • EC 4.1.2.34: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
  • EC 4.1.2.35: propioin synthase
  • EC 4.1.2.36: lactate aldolase
  • EC 4.1.2.37: Now covered by EC 4.1.2.46 [aliphatic (R)-hydroxynitrile lyase] and EC 4.1.2.47 [(S)-hydroxynitrile ketone-lyase (cyanide forming)]
  • EC 4.1.2.38: benzoin aldolase
  • EC 4.1.2.39: Deleted, identical to EC 4.1.2.37, hydroxynitrilase
  • EC 4.1.2.40: tagatose-bisphosphate aldolase
  • EC 4.1.2.41: Now included with EC 4.1.2.61, feruloyl-CoA hydratase/lyase
  • EC 4.1.2.42: D-threonine aldolase
  • EC 4.1.2.43: 3-hexulose-6-phosphate synthase
  • EC 4.1.2.44: benzoyl-CoA-dihydrodiol lyase
  • EC 4.1.2.45: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
  • EC 4.1.2.46: aliphatic (R)-hydroxynitrile lyase
  • EC 4.1.2.47: (S)-hydroxynitrile lyase
  • EC 4.1.2.48: low-specificity L-threonine aldolase
  • EC 4.1.2.49: L-allo-threonine aldolase
  • EC 4.1.2.50: 6-carboxytetrahydropterin synthase
  • * EC 4.1.2.50: 6-carboxytetrahydropterin synthase
  • * EC 4.1.2.51: 2-dehydro-3-deoxy-D-gluconate aldolase
  • * EC 4.1.2.52: 4-hydroxy-2-oxoheptanedioate aldolase
  • * EC 4.1.2.53: 2-keto-3-deoxy-L-rhamnonate aldolase
  • * EC 4.1.2.54: L-threo-3-deoxy-hexylosonate aldolase
  • * EC 4.1.2.55: 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
  • * EC 4.1.2.56: 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase
  • * EC 4.1.2.57: sulfofructosephosphate aldolase
  • * EC 4.1.2.58: 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase
  • * EC 4.1.2.59: dihydroneopterin phosphate aldolase
  • * EC 4.1.2.60: dihydroneopterin triphosphate aldolase
  • * EC 4.1.2.61: feruloyl-CoA hydratase/lyase
  • * EC 4.1.2.62: 5-deoxyribulose 1-phosphate aldolase
  • * EC 4.1.2.63: 2-hydroxyacyl-CoA lyase

EC 4.1.3: Oxo-Acid-Lyases

EC 4.1.99: Other Carbon-Carbon Lyases

EC 4.2: Carbon-Oxygen Lyases

EC 4.2.1: Hydro-lyases

EC 4.2.2: Acting on Polysaccharides

EC 4.2.3: Acting on phosphates

EC 4.2.99: Other Carbon-Oxygen Lyases

  • EC 4.2.99.1: Now EC 4.2.2.1, hyaluronate lyase
  • EC 4.2.99.2: Now EC 4.2.3.1, threonine synthase
  • EC 4.2.99.3: Now EC 4.2.2.2, pectate lyase
  • EC 4.2.99.4: Now EC 4.2.2.3, poly(β-D-mannuronate) lyase
  • EC 4.2.99.5: deleted
  • EC 4.2.99.6: Now included with EC 4.2.2.4 (chondroitin ABC lyase) and EC 4.2.2.5 (chondroitin AC lyase)
  • EC 4.2.99.7: Now EC 4.2.3.2, ethanolamine-phosphate phospho-lyase
  • EC 4.2.99.8: Now EC 2.5.1.47, cysteine synthase
  • EC 4.2.99.9: Now EC 2.5.1.48, cystathionine γ-synthase
  • EC 4.2.99.10: Now EC 2.5.1.49 EC 2.5.1.49, O-acetylhomoserine aminocarboxypropyltransferase
  • EC 4.2.99.11: Now EC 4.2.3.3, methylglyoxal synthase
  • EC 4.2.99.12: carboxymethyloxysuccinate lyase
  • EC 4.2.99.13: Now EC 2.5.1.50, zeatin 9-aminocarboxyethyltransferase
  • EC 4.2.99.14: Now EC 2.5.1.51, β-pyrazolylalanine synthase
  • EC 4.2.99.15: Now EC 2.5.1.52, L-mimosine synthase
  • EC 4.2.99.16: Now EC 2.5.1.53, uracilylalanine synthase
  • EC 4.2.99.17: Listed as EC 2.5.1.51, β-pyrazolylalanine synthase
  • EC 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase
  • EC 4.2.99.19: Now EC 4.4.1.23, 2-hydroxypropyl-CoM lyase
  • EC 4.2.99.20: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
  • EC 4.2.99.21: isochorismate lyase
  • EC 4.2.99.22: tuliposide A-converting enzyme
  • EC 4.2.99.23: tuliposide B-converting enzyme
  • EC 4.2.99.24: thebaine synthase

EC 4.3: Carbon-Nitrogen Lyases

EC 4.3.1: Ammonia-Lyases

EC 4.3.2: Amidine-Lyases

EC 4.3.3: Amine-Lyases

  • EC 4.3.3.1: 3-ketovalidoxylamine C-N-lyase
  • EC 4.3.3.2: strictosidine synthase
  • EC 4.3.3.3: deacetylisoipecoside synthase
  • EC 4.3.3.4: deacetylipecoside synthase
  • EC 4.3.3.5: 4′-demethylrebeccamycin synthase
  • EC 4.3.3.6: pyridoxal 5′-phosphate synthase (glutamine hydrolysing)
  • EC 4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase

EC 4.3.99: Other Carbon-Nitrogen Lyases

EC 4.4: Carbon-Sulfur Lyases

EC 4.4.1: Carbon-sulfur lyases (only sub-subclass identified to date)

EC 4.5: Carbon-Halide Lyases

EC 4.5.1: Carbon-halide lyases (only sub-subclass identified to date)

  • EC 4.5.1.1: DDT-dehydrochlorinase
  • EC 4.5.1.2: 3-chloro-D-alanine dehydrochlorinase
  • EC 4.5.1.3: dichloromethane dehalogenase
  • EC 4.5.1.4: L-2-amino-4-chloropent-4-enoate dehydrochlorinase
  • EC 4.5.1.5: S-carboxymethylcysteine synthase

EC 4.6: Phosphorus-Oxygen Lyases

EC 4.6.1: Phosphorus-oxygen lyases (only sub-subclass identified to date)

EC 4.7: Carbon-phosphorus lyases

EC 4.7.1: Carbon-phosphorus lyases (only sub-subclass identified to date)

  • EC 4.7.1.1 α-D ribose 1-methylphosphonate 5-phosphate C-P-lyase *

EC 4.8: Nitrogen-oxygen lyases

EC 4.8.1: Hydro-lyases

EC 4.98: ATP-independent chelatases

EC 4.98.1: Forming coordination complexes

EC 4.99: Other Lyases

EC 4.99.1: Sole sub-subclass for lyases that do not belong in the other subclasses

References

  1. ^ "ExplorEnz – The Enzyme Database".
  2. ^ McDonald, A.G.; Boyce, S.; K.F., Tipton (2009). "ExplorEnz: the primary source of the IUBMB enzyme list". Nucleic Acids Res. 37 (Database issue): D593 – D597. doi:10.1093/nar/gkn582. PMC 2686581. PMID 18776214.
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