List of EC numbers (EC 6)

This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee.[1] The database is developed and maintained by Andrew McDonald.[2]

EC 6.1: Forming Carbon-Oxygen Bonds

EC 6.1.2: Acid—alcohol ligases (ester synthases)

EC 6.1.3: Cyclo-ligases

EC 6.2: Forming Carbon-Sulfur Bonds

EC 6.2.1: Acid-Thiol Ligases

EC 6.2.2: Amide—thiol ligases

EC 6.3: Forming Carbon-Nitrogen Bonds

EC 6.3.1: Acid—Ammonia (or Amine) Ligases (Amide Synthases)

EC 6.3.2: Acid—Amino-Acid Ligases (Peptide Synthases)

  • EC 6.3.2.1: pantoate—β-alanine ligase (AMP-forming)
  • EC 6.3.2.2: glutamate—cysteine ligase
  • EC 6.3.2.3: glutathione synthase
  • EC 6.3.2.4: D-alanine—D-alanine ligase
  • EC 6.3.2.5: phosphopantothenate—cysteine ligase (CTP)
  • EC 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • EC 6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
  • EC 6.3.2.8: UDP-N-acetylmuramate—L-alanine ligase
  • EC 6.3.2.9: UDP-N-acetylmuramoyl-L-alanine—D-glutamate ligase
  • EC 6.3.2.10: UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase
  • EC 6.3.2.11: carnosine synthase
  • EC 6.3.2.12: dihydrofolate synthase
  • EC 6.3.2.13: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase
  • EC 6.3.2.14: enterobactin synthase
  • EC 6.3.2.15: Deleted, The activity observed is due to EC 6.3.2.10, UDP-N-acetylmuramoyl-tripeptideD-alanyl-D-alanine ligase
  • EC 6.3.2.16: D-alanine—alanyl-poly(glycerolphosphate) ligase
  • EC 6.3.2.17: tetrahydrofolate synthase
  • EC 6.3.2.18: γ-glutamylhistamine synthase
  • EC 6.3.2.19: The ubiquitinylation process is now known to be performed by several enzymes in sequence, starting with EC 6.2.1.45 (ubiquitin-activating enzyme E1) and followed by several transfer reactions, including those of EC 2.3.2.23 (E2 ubiquitin-conjugating enzyme) and EC 2.3.2.27 (RING-type E3 ubiquitin transferase)
  • EC 6.3.2.20: indoleacetate—lysine synthetase
  • EC 6.3.2.21: [[The reaction is performed by the sequential action of EC 6.2.1.45 (ubiquitin-activating enzyme E1), several ubiquitin transferases and finally by EC 2.3.2.27 (ubiquitin transferase RING E3 (calmodulin-selective))|The reaction is performed by the sequential action of EC 6.2.1.45 (ubiquitin-activating enzyme E1), several ubiquitin transferases and finally by EC 2.3.2.27 [ubiquitin transferase RING E3 (calmodulin-selective)]]]
  • EC 6.3.2.22: Now EC 6.3.1.14, diphthine—ammonia ligase.
  • EC 6.3.2.23: homoglutathione synthase
  • EC 6.3.2.24: tyrosine—arginine ligase
  • EC 6.3.2.25: tubulin—tyrosine ligase
  • EC 6.3.2.26: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
  • EC 6.3.2.27: [[The activity is covered by two independent enzymes, EC 6.3.2.38 N^2-citryl-N^6-acetyl-N^6-hydroxylysine synthase, and EC 6.3.2.39, aerobactin synthase|The activity is covered by two independent enzymes, EC 6.3.2.38 N2-citryl-N6-acetyl-N6-hydroxylysine synthase, and EC 6.3.2.39, aerobactin synthase]]
  • EC 6.3.2.28: Now EC 6.3.2.49, L-alanine-L-anticapsin ligase
  • EC 6.3.2.29: cyanophycin synthase (L-aspartate-adding)
  • EC 6.3.2.30: cyanophycin synthase (L-arginine-adding)
  • EC 6.3.2.31: coenzyme F420-0:L-glutamate ligase
  • EC 6.3.2.32: coenzyme γ-F420-2:α-L-glutamate ligase
  • EC 6.3.2.33: tetrahydrosarcinapterin synthase
  • EC 6.3.2.34: coenzyme F420-0:L-glutamate ligase
  • EC 6.3.2.35: D-alanine—D-serine ligase
  • EC 6.3.2.36: 4-phosphopantoate—β-alanine ligase
  • EC 6.3.2.37: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
  • EC 6.3.2.38: N2-citryl-N6-acetyl-N6-hydroxylysine synthase
  • EC 6.3.2.39: aerobactin synthase
  • EC 6.3.2.40: cyclopeptine synthase
  • EC 6.3.2.41: N-acetylaspartylglutamate synthase
  • EC 6.3.2.42: N-acetylaspartylglutamylglutamate synthase
  • EC 6.3.2.43: [amino-group carrier protein]—L-2-aminoadipate ligase
  • EC 6.3.2.44: pantoate—β-alanine ligase (ADP-forming)
  • EC 6.3.2.45: UDP-N-acetylmuramate—L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioate ligase
  • EC 6.3.2.46: fumarate—(S)-2,3-diaminopropanoate ligase
  • EC 6.3.2.47: dapdiamide synthase
  • EC 6.3.2.48: L-arginine-specific L-amino acid ligase
  • EC 6.3.2.49: L-alanine—L-anticapsin ligase
  • EC 6.3.2.50: tenuazonic acid synthetase
  • EC 6.3.2.51: phosphopantothenate—cysteine ligase (ATP)
  • EC 6.3.2.52: jasmonoyl—L-amino acid ligase
  • EC 6.3.2.53: UDP-N-acetylmuramoyl-L-alanine—L-glutamate ligase
  • EC 6.3.2.54: L-2,3-diaminopropanoate—citrate ligase
  • EC 6.3.2.55: 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase
  • EC 6.3.2.56: staphyloferrin B synthase
  • EC 6.3.2.57: staphyloferrin A synthase
  • EC 6.3.2.58: D-ornithine—citrate ligase
  • EC 6.3.2.59: 3-methyl-D-ornithine—L-lysine ligase
  • EC 6.3.2.60: glutamate—[amino group carrier protein] ligase
  • EC 6.3.2.61: tubulin-glutamate ligase
  • EC 6.3.2.62: β-tubulin-glutamate ligase

EC 6.3.3: Cyclo-Ligases

  • EC 6.3.3.1: phosphoribosylformylglycinamidine cyclo-ligase
  • EC 6.3.3.2: 5-formyltetrahydrofolate cyclo-ligase
  • EC 6.3.3.3: dethiobiotin synthase
  • EC 6.3.3.4: (carboxyethyl)arginine β-lactam-synthase
  • EC 6.3.3.5: O-ureido-D-serine cyclo-ligase
  • EC 6.3.3.6: carbapenam-3-carboxylate synthase
  • EC 6.3.3.7: Ni-sirohydrochlorin a,c-diamide reductive cyclase

EC 6.3.4: Other Carbon-Nitrogen Ligases

EC 6.3.5: Carbon-nitrogen ligases with glutamine as amido-N-donor

  • EC 6.3.5.1: NAD+ synthase (glutamine-hydrolysing)
  • EC 6.3.5.2: GMP synthase (glutamine-hydrolysing)
  • EC 6.3.5.3: phosphoribosylformylglycinamidine synthase
  • EC 6.3.5.4: asparagine synthase (glutamine-hydrolysing)
  • EC 6.3.5.5: carbamoyl-phosphate synthase (glutamine-hydrolysing)
  • EC 6.3.5.6: asparaginyl-tRNA synthase (glutamine-hydrolysing)
  • EC 6.3.5.7: glutaminyl-tRNA synthase (glutamine-hydrolysing)
  • EC 6.3.5.8: Now EC 2.6.1.85, aminodeoxychorismate synthase. As ATP is not hydrolysed during the reaction, the classification of the enzyme as a ligase was incorrect
  • EC 6.3.5.9: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
  • EC 6.3.5.10: adenosylcobyric acid synthase (glutamine-hydrolysing)
  • EC 6.3.5.11: cobyrinate a,c-diamide synthase
  • EC 6.3.5.12: Ni-sirohydrochlorin a,c-diamide synthase
  • EC 6.3.5.13: lipid II isoglutaminyl synthase (glutamine-hydrolysing)

EC 6.4: Forming Carbon-Carbon Bonds

EC 6.4.1: Ligases that form carbon-carbon bonds (only sub-subclass identified to date)

EC 6.5: Forming Phosphoric Ester Bonds

EC 6.5.1: Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

EC 6.6: Forming Nitrogen-Metal Bonds

EC 6.6.1: Forming Coordination Complexes

EC 6.7: Forming nitrogen-nitrogen bonds

EC 6.7.1: Forming diazo bonds

  • EC 6.7.1.1: 3-amino-2-hydroxy-4-methoxybenzoate

References

  1. ^ "ExplorEnz – The Enzyme Database".
  2. ^ McDonald, A.G.; Boyce, S.; K.F., Tipton (2009). "ExplorEnz: the primary source of the IUBMB enzyme list". Nucleic Acids Res. 37 (Database issue): D593 – D597. doi:10.1093/nar/gkn582. PMC 2686581. PMID 18776214.
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